The victim, whose name has not yet been released, was found shot multiple times in the 400 block of Jones Street, near Ellis Street, at about 12:20 a.m.
Police spokesman Officer Albie Esparza said the victim had gotten into a verbal dispute with the three men and then punched one of them in the face.
The man who was punched then pulled out a gun and shot the victim multiple times, Esparza said. He was pronounced dead at the scene.
The three suspects–described only as black men about 20 years old, one reportedly with dreadlocks–ran north on Jones Street and then west on O’Farrell Street, police said.
Police found a semiautomatic handgun believed to have been used in the shooting stashed in a mailbox in the 500 block of O’Farrell Street, Esparza said.
No arrests have been made in the case.
Police have been canvassing the neighborhood for witnesses. Anyone with information about the shooting is asked to call the Police Department’s anonymous tip line at (415) 575-4444 or text TIP411.
The shooting is San Francisco’s 31st homicide this year.
2:02 AM: A man was shot multiple times and killed in San Francisco’s Tenderloin neighborhood early this morning, a police spokesman said.
Officers responded to a report of shots fired in the 400 block of Jones Street at around 12:25 a.m., San Francisco police Officer Albie Esparza said.
Arriving police found a man between 30 and 40 years old who had been shot several times. The victim was pronounced dead at the scene.
Police are now searching for two suspects, one of whom was believed to have dreadlocks. The two men were last seen running east on O’Farrell Street.
A semi automatic handgun was found discarded about a block away from the shooting, which police believe was likely the weapon involved in the homicide.
The killing remains under investigation.